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From DiMarzio's website: "All of our full-size humbuckers except the X2N® and D Activator-X™ are available in two polepiece spacings. F-spacing refers to the wider of the two spacings. For proper string alignment and balanced output, F-spaced humbuckers should be used in the bridge position on all guitars with string spacing at the bridge of 2.1" (53 mm) or greater. On these guitars, if the nut width is 1-11/16” (43 mm) or greater, F-spaced pickups can be used in the neck position as well."