"For open chord tunings (I use quite a few odd ones), I have a Fender Squier Stratocaster with a trilogy bridge, raised nut, wired with one normal Fender neck pick up, one Hot Rail and one Cool Rail pick up. With this particular axe, I tend to use open G and E tunings that work well for electric slide playing."more
"and then I use the Seymour Duncan Hot Rails in the lead position on all of them. Fender built me an exact replica of my ‘61, exactly the same with the wear marks on the guitar and they put in the same pickups for me. It was awesome. But the Seymour Duncan Hot Rails is the loudest pickup made known to man, and that’s why I like it. It just really, really, really cranks – it gives you a lot more overdrive then a regular stock Fender pickup."more
In [this article on the Seymour Dunan website](https://www.seymourduncan.com/blog/backstage-pass/a-trip-to-daniel-lanois-house), custom shop manager Maricela “MJ” Juarez and tech guru Scott Miller visit Lanois to deliver new pickups and encounter two of his Strats, which are equipped with Hot Rails pickups, in the process.more
In this photo, Dave Murray can be seen using Hot Rails pickups. This is confirmed in [this article](http://www.seymourduncan.com/blog/backstage-pass/iron-maiden-and-seymour/) on Seymour Duncan's official website. It says, ''Dave Murray uses a Strat with Hot Rails pickups in all three positions'more
Edit: If you look around online you'll find he actually uses the Lace Sensor pickups for neck and middle and the Seymour Duncan Hot Rails for the bridge, which is not what he says in the following quote. "I actually am using Fender Lace Sensors in my neck and bridge position, and then I use the Seymour Duncan Hot Rails in the lead position on all of them. Fender built me an exact replica of my ‘61, exactly the same with the wear marks on the guitar and they put in the same pickups for me. It was awesome. But the Seymour Duncan Hot Rails is the loudest pickup made known to man, and that’s why I like it. It just really, really, really cranks – it gives you a lot more overdrive then a regular stock Fender pickup. As far as the Lace Sensors — they’re quiet. A Strat is a notorious buzzing guitar – makes that telltale buzz on stage. They are noisy pickups because they are single coil pickups and they pickup AM radio and God knows what else, but the Lace Sensors are dead quiet. It takes that vintage sound of a Strat and just improves upon it."more
A very awesome pick up indeed. I've heard people have felt its a bit dark and can be muddy sounding but I personally have never had that problem in my strat for the shortish time I used it in there. I still have it waiting for when I buy a new strat as it has been replaced by a SH-4 JB. Very crunchy clean tone indeed and very very mid range orientated, just sounds awesome to me. Great bass response and the highs aren't too over the top or piercing like some pick ups can be in my opinion. I used it with a coil tap so if I wanted to have that more traditional strat tone I could do. Cleans up pretty good to when you roll of the volume. If you want to do anything from the heavy alt rock of the 90's, well grunge really to stuff like maiden etc. excellent pick up
I took interest in this particular pickup when I saw a video on youtube demonstrating the "djentability" of a strat against an Ibanez 8 string. The video has since been taken down, much to my disappointment. Surprisingly the strat turns out to yield a more pleasant tone and I decided to give it a go. I was fortunate enough to find a steal of a deal on the second hand market (about 35 USD) so I bought it and installed it onto the bridge position of my Squier Affinity Strat (note that this is an earlier incarnation of the affinity series so the quality is roughly equivalent of that of a Squier standard).
The result was within my expectations - high gain, beefy and mid-rich tone distinct to the rest of the pickups on the guitar (both being single coils). When engaged, it has a significant volume increase which some may find bothersome, but that is only reasonable when you pit a high output humbucker against cheap factory single coils. Despite being great for rock and metal tones, the pickup could be a little bland. It lacks a lot of dynamics, and the clean tend to be a bit compressed and duller than that from a single coil.
Then I switched to position 2 on the pickup switch, which was when I discovered the tone I've been searching for several years. Crunchy, not too full sounding and touch-sensitive, with the sensitivity of a humbucker but the clarity and snap of a single coil. On lower gain settings - whether it be lead or rhythm - this combination shines. It's crunchy, bitey and....well it's pretty hard to describe, but I really can't recommend it more. Oh right, and slapping is strictly mandatory on that combination. It's slap heaven.
Anyways, this is a very solid humbucking pickup aimed towards rock and metal players who want a thick sound. Blend it with the middle pickup if you have one. You'll be surprised.