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I don't have a great deal of input here—I use this pedal primarily to thicken my tone a bit. It does have two subs down, one octave up, and a polyphonic and monophonic options (via toggle switch). I have not tested it with my fuzz, but I can only imagine that it will sound fabulous!
Let's briefly talk about the Toneprint feature. I think it is a good idea, and had about an hour of fun with it. I really hope TC throws some more resources at their application's functionality and UI design. It's not very well thought out. It's been on the market long enough where you think it would have been upgraded. The iPhone app is clunky and crash-prone at this point...
The low sub down is nice to have, but it's more than my rig can handle—Mesa Boogie 5:25 and a Vox AC4. Maybe fun with a bass guitar!