my pedal drawer is pretty simple and mainly MIDI right now... after having a version that could control some head switching with a Nova system, octave fuzz and analog chorus I realized I didn't use half the cool presets I was making, so the current iteration put all the amps on all the time and went down to bare bones effects:
TC Polytune, Brian May Treble Booster (always on), TC Nova Drive in preset mode, Radial Tonebone ABY (one side to a dry amp), TC Flashback X4 (always on at least as a SUPER subtle tape slap) to 2 wet amps
using the shitty behringer FCB1010 to change patches and tap tempo, so far so good with her, but I don't do a ton of stimping and only have like 6 patches right now I think
last I played with a drummer I just used 2 amps w/stereo delay and didn't use my dry output (ac30HW and this old traynor I bought earlier this year) and was hella loud in a good way, bright, present, full but not harsh.... but its cool to throw the matchless in too for the ef86 channel and dual rectifier squish too if I can get away with that much more level (6x12's is a lot of speakers, particularly throwing 100+ watts of potential power)... obviously nothing is set up to be really clean with my bridge pickups at full volume on the guitar... its a rock rig
I really like letting my amplifiers do the distorting and really work the speakers hard. As opposed to bass where Boom's rig is more my style. I like tons of clean headroom and any 'grunt' should be out front so you can really narrow in on what frequency ranges are grinding. Though I do prefer tube to solid state for bass as long as its excessively loud and punchy tube amplification.