"Preamp pedals going into a Two Notes Cab M"
See, that's the problem to start with. If you want to get the Santana tone you have to start with the proper gear. Carlos Santana used Dumble-style heads with rack stereo delays. And what do those Dumble heads have that the preamp pedals don't? That's right, tube power section. You can't replicate the feel and response of the real deal.
Yes, I know the tube amp market is out of control right now due to the ongoing tube shortage; however, if you're not using the proper equipment, then no matter how much time you spend trying to tweak the pedals, you won't get that sound. My suggestion is to sell those pedals and the CAB M, and save up for the real amps. If you can't stretch for the real Dumble, then at least go with the Synergy SYN-1 or SYN-2. You can easily get an AC30-style tone with the Morgan AC module, and for stereo delay, you can't go wrong with either a Strymon TimeLine or an Eventide TimeFactor.
Preamp pedals are convenient and all, but they all use the same FET technology and therefore sound and feel rather sterile and lifeless compared against the real deal. You can try adding more pedals to try and fix this; however, you cannot add what isn't there. The same can be said for the modellers and profilers - they all use similar DSP chips trying to sound like the real thing but then they all cut corners in the feel and response of the real amp, not to even mention how subpar the effects on the modellers are. (Believe me, I know this from my experience with the Failure Audio Crap-FX III. Absolute useless piece of garbage that frankly, I highly do NOT recommend anyone play through it if they care about respecting the originality of the guitar tones.)
I know tube amps will be expensive, but it would be unrealistic for me to recommend subpar gear to try and achieve a certain tone. You get what you pay for.