Esoterik Guitars is a high-end electric guitar company founded in 2010 by luthier Ryan Cook, who previously worked at KB Custom Guitars, Ernie Ball Music Man, and National Reso-Phonic Guitars before launching his own brand in San Luis Obispo, California. The company focuses on neck-through electric guitars built in 6, 7, and 8-string configurations, with extended-range and baritone options aimed at modern progressive and metal players.

The core lineup centers on the DR1, DR2, and DR3 models, alongside baritone-focused designs such as the LK27 and FR27. Instruments feature neck-through construction with the neck woods extending from headstock through the body center, which the brand emphasizes for sustain, tuning stability, and upper-fret access. Initial production was handcrafted in California, and later models are built at World Musical Instruments in South Korea to Esoterik's specifications.

Esoterik occupies a niche between boutique custom shops and mass-production brands, offering through-neck extended-range guitars at price points below most comparable small-builder instruments.

Esoterik Guitars has 2 products cataloged on Equipboard, including Solid Body Electric Guitars. Their gear is featured by 3 artists, with the strongest followings in Rock and Metal. Notable users include Deron Miller, Nick Rossi, and Michael Crain.