Manson Guitar Works is a British electric guitar manufacturer based in Devon, England. Its origins trace back to luthier Andy Manson, who began building acoustic instruments in the late 1960s, before his younger brother Hugh Manson joined the family trade and focused on electric guitar making. After relocating from Crowborough, Sussex to Exeter, Hugh established the workshop and an associated retail operation known as Mansons Guitar Shop.

The brand builds custom and semi-custom electric guitars and basses, with model families including the M-Series, Meta Series, ORYX, Verona, and a range of signature instruments. Manson also produces effects pedals such as the Supermassive Black Fuzz. Early semi-custom electric designs included the Kestrel and Merlin series.

Manson is closely associated with Muse frontman Matt Bellamy, who has played Manson instruments since the early 2000s and acquired a majority stake in the company in 2019. Other notable players linked to the brand include Dave Grohl, John Paul Jones, and Skindred guitarist Mikey Demus, whose MD model is part of the signature lineup.

Manson Guitar Works has 1 product cataloged on Equipboard, including Solid Body Electric Guitars. Their gear is featured by 1 artist, with the strongest followings in Electronic and Rock. Notable users include Morgan Nicholls.