Masotti is an Italian builder of guitar amplifiers and signal-chain devices based in Farnese, on the border of Lazio and Tuscany. Founded in 1998 as a collaboration between guitarist Pierangelo Mezzabarba and engineer Marco Masotti, the company operates under the name Masotti Guitar Devices and positions itself as a partnership between engineers and players aimed at high-end tone for electric guitar.

The product range covers tube amplifier heads such as the X100M, slave power amps, speaker cabinets, preamps, effects power supplies, and overdrive, boost, loop and sampler pedals. Masotti also builds custom floorboard units and complete gig rigs tailored to individual players. The brand later spawned the related Mezzabarba Custom Amplification line, which grew out of the original Masotti Guitar Devices work.

Italian session and touring guitarists including Giacomo Castellano and Alex De Rosso have been associated with the brand through its artist roster and demos.

Masotti has 3 products cataloged on Equipboard, including Guitar Amplifier Heads, Guitar Preamps, and Buffer Pedals. Their gear is featured by 1 artist, with the strongest followings in Blues. Notable users include Awesome John.