Signature by Tanglewood is a line of Japanese-made electric guitars produced for the UK-based Tanglewood Guitars brand by the Fujigen factory in Japan. The sub-brand emerged in the mid-2000s as a higher-tier offering distinguished from Tanglewood's mainline instruments, with the word "Signature" appearing prominently on the headstock. Production was limited to approximately 1,000 units across the range.

The lineup centers on single-cutaway models closely modeled after the Gibson Les Paul template, including the STR-1, the ST1, and the TSB-58, along with variants such as the TSB-62 and the TSB-C58 LTD2. These guitars typically feature solid mahogany bodies with flame maple tops, set necks with a 24¾-inch scale, rosewood fingerboards, tune-o-matic bridges with stop tailpieces, and humbucking pickups — the TSB-58 shipped with Entwistle HV58 humbuckers, and several STR-1 variants were fitted with Gotoh hardware.

Because the instruments came out of the same Japanese factory associated with Fender Japan and Ibanez Prestige work, owners and reviewers on forums such as My Les Paul Forum, The Fretboard, and the Tokai Forum frequently compare the build and feel favorably to Japanese Tokai Les Paul copies. The limited production run has given Signature-branded Tanglewoods a following on the secondary market, where they tend to be valued for fit, finish, and playability relative to their original price point.

Signature by Tanglewood has 2 products cataloged on Equipboard, including Solid Body Electric Guitars.