Oh man I love this question.
I would have to be my 1978 Fender Telecaster Custom, black finish, maple neck.
At the end of the day, it's a Tele with a Wide Range humbucker in the neck position. Fender produced it between 1972 and 1981, then reissued as the 1972 Telecaster Custom. Keith Richards kinda made it famous, so I guess there's that. But man, I love this guitar. If my house caught fire and I had 30 seconds to grab some stuff and get out, this guitar would definitely make the short list.
It's got Tele twang, but you can also get really smooth and creamy tones from the humbucker, and set to the middle position it's the best of both worlds. I never knew this until recently but apparently it's a couple lbs heavier than a standard Tele since Fender made it with denser wood at the time, but it still feels very light to me. It's just so easy to pick up and play.
It's like a sandwich. Even the best sandwich out there isn't exactly gourmet food, but this particular one is made with fresh baked ciabatta bread, aioli, sliced raddish, and sliced turkey breast from a turkey that was sniped from a helicopter just hours prior to consuming. That's how I feel about this guitar.