Palir Guitars is an American electric guitar and bass builder established in 2013 and based in Southern Louisiana. The company is run by John and Katie Palir, who handle the business as a husband-and-wife operation. Palir's tagline — "Comfort, Tone, and Clarity" — reflects the brand's focus on building bolt-on, T-style and S-style instruments designed around player ergonomics, paired with a wide range of artistic and custom finishes.

The lineup centers on a small set of named models including the Titan, Stinger, Imperial, Phoenix, Striker "50," Striker IV, and the Thunder IV and V basses. Builds typically use Swamp Ash or Alder bodies and maple necks, and are commonly fitted with boutique pickups from makers like Lollar and Porter alongside Emerson electronics, with extensive custom-spec options offered through a dealer network.

Palir instruments are sold through specialty retailers such as The Music Zoo, Distinctive Guitar, Matt's Music Center, Wildcat Guitars, and Rebel Guitars, as well as on Reverb. The brand has built an international following and has been associated with players including Luke Combs, Colbie Caillat, Billy F. Gibbons, Andy Grammer, Jason Mraz, David Crowder, Kirk Franklin, and Casey James.

Palir has 4 products cataloged on Equipboard, including Solid Body Electric Guitars. Their gear is featured by 2 artists, with the strongest followings in Rock. Notable users include Billy Gibbons and Ejima Harushi.