Black Francis

In this Rig Rundown YouTube video at 17:02, you can see a Vox Python attached to Black Francis’ Gibson SG

In his December 2006 interview with Vintage Guitar Magazine he's asked:

Do you collect guitars?

BF: - For a while, I was really into ’60s Teles, and then a few years back, a bunch of them got stolen. So to sort of “celebrate,” I went out and bought my first ’50s Tele – a ’57 – which initially felt weird, but eventually became my main guitar up until last year, when my brother showed up at a gig in L.A. at the beginning of the Pixies tour with a ’53 Telecaster. He just gave it to me at the gig, and it sounded, actually, too intense. But eventually I started playing it, and now it’s my main guitar.

In Premier Guitar's Pixies Rig Rundown of February 12, 2014 it tells us:

Thompson keeps it single-coil simple with two stock vintage Teles and two ’50s Martins—a D-28 and a D-18. When he needs an angrier tone, he relies on the P-90 in his cherry 1963 Gibson SG Jr.

In Premier Guitar's Pixies Rig Rundown of February 12, 2014 it tells us:

Thompson keeps it single-coil simple with two stock vintage Teles and two ’50s Martins—a D-28 and a D-18. When he needs an angrier tone, he relies on the P-90 in his cherry 1963 Gibson SG Jr.

In Premier Guitar's Pixies Rig Rundown of February 12, 2014 it tells us:

Thompson keeps it single-coil simple with two stock vintage Teles and two ’50s Martins—a D-28 and a D-18. When he needs an angrier tone, he relies on the P-90 in his cherry 1963 Gibson SG Jr.

Black Francis, the Pixies frontman, is confirmed to use the Healy Guitars Healer. This is evidenced by an Instagram post from Healy Guitars, which states they crafted a custom Healer guitar for him, incorporating unique features such as one of his wisdom teeth and maple from his property. Additionally, Black Francis is seen performing with this guitar during live performances from 2023.