Science Amplification is a boutique tube amplifier builder founded in 2009 in Olympia, Washington, by Alex, a longtime guitarist and bassist with a focus on hand-wired tube amp design. Amplifiers are designed, built, and tested in Portland, Oregon, while the dedicated cabinet shop remains in Olympia under master woodworker Jeff Murrow.

The brand's lineup centers on high-wattage tube heads including the Mother, Totality, and Earthling, along with matching guitar and bass cabinets, impulse responses, and the Mother Preamp pedal — a dual-channel tube pedal that distills the Mother's voicing into a pedalboard-friendly format. The Mother itself draws on the vintage high-wattage sounds of the early 1970s (often compared to the Hiwatt DR201) with an added overdrive input and expanded tonal range.

Builds are made to order with extensive customization options across tolex, stain, hardware, grill cloth, and speakers, giving the company a reputation among guitarists and bassists looking for handbuilt, heavyweight tube gear outside the mass-production mainstream.

Science Amplification has 5 products cataloged on Equipboard, including Guitar Amplifier Heads, Amp & Cabinet Simulators, and Bass Amplifier Cabinets. Their gear is featured by 4 artists, with the strongest followings in Rock and Folk, World, & Country. Notable users include Scott Scharinger, Ahmoudou Madassane, and Alex Gaziano.