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Science Amplification Mother MKIII Head Amp

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Page last updated Jun 28, 2026

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The Mother MkIII is an 50w, 100w or 200w Tube Amp by Science Amplification hand-build in the USA.

.....and comes in 2 Versions: A no-frills high-headroom single channel version and a dual channel version with additional Gain and master Loudness controls for it's 2nd, wide range higher gain channel.

The Mother is still equally accommodating for bass or guitar.

The Single Channel version features only Channel A from the dual channel model, great for a pedal platform.

This single channel version goes from clean to vintage crunch with plenty of headroom for even the most towering fuzz and distortion pedals.

The tone is clear, but never fizzy.

The Dual Channel version adds a second wide range channel that takes the tonality of Channel A, and keeps on going into higher levels of saturation, from edge-of-break-up, to crunch to crushing gain with dynamics intact. In addition to the Mother's wide spectrum of gain, its EQ is equally wide ranging.

The flexible EQ section begins with the unique 4-position rotary Depth knob, which sets the overall bass extension, low-mid voice, and low-end breakup characteristics in the front end of the amplifier. From there, the interactive 3-band (Bass, Middle, Treble) EQ sculpts your tone.

The bass shapes the lows voicing set with the Depth, and the unique mid control goes from completely scooped to vocal midrange.

The Treble controls the overall high-end, and for further control of the amplifier's upper-harmonic content, the Absence shapes the the tone from present and searing to dark and fogged-out.

And finally, the front panel's Loudness control(s) transparently varies the overall volume of the amp down to bedroom levels without sucking your tone.

The Mother MkIII is available in 50W, 100W, or 200W, and can be fitted with the optional ultra-transparent series Ghost effects loop.

More details in the Manual for the Dual Channel Amp.

Available in single and dual channel versions

4-position rotary Depth control to tailor front end low and low-mid response

High headroom to gritty Channel A

Wide-range B Channel from edge-of-breakup to punchy high gain

Bass, Middle, Treble EQ

Harmonic-shaping Absence control

Master Loudness control (x2 on dual channel version)

Two switchable 4, 8, or 16 Ohms outputs

Available in 50W or 100W with your choice of 6L6 or EL34 output tubes, or 200W powered by 4 x KT88 output tubes

3 x 12AX7 preamp tubes and 1 x 12AT7 driver tube

Rugged, high-reliability, and serviceable, low-noise construction

All-tube signal path

Optional series buffered effects loop

User-adjustable bias control and test points on chassis for easy biasing and tube swaps

Included 1-Button Footswitch with LED (dual channel version)

Custom void-free Baltic birch cabinet

12ga custom laser-machined aluminum chassis

Black powder coated aluminum control panels

Dimensions: 24” W x 10.875” D x 11” H (11.625 including rubber feet)

Weight - 50W: 40 lbs, 100W: 45 lbs, 200W 60 lbs

Handbuilt in the USA

Owner's manual

Science Amplification Mother MKIII Head Amp User Manual

Product specs

Amp Type

tube

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Fuzzed Drones

One of the most versatile amps! Science Amplification / MOTHER 100

Fuzzed Drones

One of the BEST modern day Amps! Science // Mother

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Owner Insights

We analyzed real musician discussions from forums and Reddit to find what players love, question, and tweak about Science Amplification Mother MKIII Head Amp.

Build quality

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The aesthetic design of Science Amps, including a clean logo, attracts users, enhancing the visual appeal alongside its sonic capabilities.
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Noted for having a robust build, Science amps exhibit superior construction with features like extra fusing and external bias test points, surpassing Verellen's craftsmanship.
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Value and pricing

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Science Amps offer a flexible payment system during the build wait, with 20% down and the ability to pay in installments, easing the purchase of high-end amps.
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Price range varies from $2,199 for a 50W single channel to $2,749 for a 200W dual channel, offering competitive pricing against larger brands.
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Comparisons

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The Science Earthling is suggested for those seeking Matamp-style tones, as it is based on a vintage GT120 circuit, while the Mother is better for modern high-gain needs.
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The amp's gain is described as big and loose, not tight like an Engl, necessitating pedals for a modern, tight sound.
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Compared to the Decolonizer, the gain falls short of Soldano territory but surpasses expectations for high-gain needs.
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It offers a tonal experience likened to a Hiwatt with Ampeg V4 preamp characteristics, providing a clean and flat response with a passive midrange.
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User experience

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Science Amps’ customer service is praised as exceptional, with the founder, Alex, being highly responsive and supportive, even providing guidance on non-Science amps.
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Buyers report a wait time of up to 14 months, indicating high demand and suggesting planning ahead for prospective purchasers.
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There's significant praise for the amp's loudness and tonal range, with users noting its capability to fill venues with powerful sound.
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Owners are surprised by the high gain in Channel B, which is substantial without needing additional gain pedals, suitable for death/sludge metal styles.
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Features and functionality

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The dual-channel Mother MKIII offers a second channel with significant mid to higher gain, ideal for tight and chuggy tones rather than sludgy distortion.
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The amp features a 200W output with KT88s and 3x 12AX7 preamp tubes, drawing design inspiration from early Matamp/Orange preamps.
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The amp includes a half-power switch allowing for quieter playing without loss of tonal quality, making it suitable for apartment use.
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Use cases and applications

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The Mother MKIII's clean channel produces a huge, bright, aggressive Hiwatt-like sound, making it a favorite for bass players seeking clarity and power.
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The amp is versatile enough for both guitar and bass, demonstrated by live performances where it stood out among other gear.
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The Science Mother MKIII head is effectively used in baritone/bass rigs, praised for its ability to deliver massive sound.
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Alex Gaziano

Guitarist, Audio Engineer

Kidcrash

Verified via Photo

In this picture, Alex can be seen posing with a Science Amps Mother Head. An amp which he co-created.

Juan Cordero

Singer, Guitarist

Verified via YouTube

In the YouTube Shorts video by Juan Cordero (https://www.youtube.com/shorts/2NZ2BSaMmUc), a Science Amplification Mother MKIII Head Amp can be seen as part of his live guitar rig. The amplifier head is identifiable by its distinctive front panel and enclosure design. Juan Cordero appears to use the Mother MKIII as his primary guitar amplifier, providing the high-headroom, powerful clean foundation and dynamic response that complements his shoegaze and alternative rock tones. The amp head is visible during the performance, indicating it is a core component of his live setup.