PreSonus was founded in 1995 in Baton Rouge, Louisiana by Jim Odom and Brian Smith, electrical engineering graduates of Louisiana State University. Starting from modest beginnings in Odom's garage, the company grew into a well-known manufacturer of professional audio equipment spanning audio interfaces, digital mixing consoles, studio monitors, microphone preamps, and digital audio workstation (DAW) software.

The company built a reputation for making professional-caliber recording tools accessible to project studio owners and working musicians. The FirePod audio interface was among the first widely adopted multi-channel FireWire interfaces for home and project studios. The StudioLive series of digital mixing consoles, launched in 2009, combined live sound mixing with integrated recording capabilities and found a following across live performance, houses of worship, and studio tracking. PreSonus also developed the Studio One DAW (later rebranded Studio Pro), which gained a strong user base for its streamlined workflow and tight integration with PreSonus hardware.

The product lineup covers both studio and live sound applications, including the AudioBox and Studio-series audio interfaces, the EarMix 16M personal monitor mixer, NSB-series network stage boxes, and a range of studio monitors and loudspeakers. The DigiMax series of microphone preamps with ADAT output has been a long-running option for engineers looking to expand analog input count on their interfaces and consoles.

PreSonus has 237 products cataloged on Equipboard, including Audio Interfaces, Active & Passive Monitors, and Mixers. Their gear is featured by 198 artists, with the strongest followings in Electronic, Rock, and Pop. Notable users include Glenn Rosenstein, Dana James Presson, and Deadmau5. PreSonus's catalog spans the full price spectrum — from entry-level options to high-end flagships.