Hetfield: We’re really pleased with Fractal. It’s amazing. For my rig, we went into the studio and put some sounds into it—a combination of my Mesa/Boogie amps mixed in with a little bit of my Diezel sound. The clean sounds are from the Roland JC-120. On stage, Mesa 2:Ninety power amps drive my cabinets, but those cabs aren’t miked at all. They’re only there for my monitoring, for getting feedback, and for just feeling it. The Fractal is going direct to the board.

Matt uses the Axe FX for his effects and the Kemper amps to take care of the amp modeling.

14:15 Kirk Hammets guitar tech say's he uses the Fractal axe fx

"I used to have what was the size of refrigerators for racks with all sorts of gear because back then there was only one thing that did the chorus, one thing that did delay, and one thing that did phase. So then multiple processors came along and most of them sounded like crap to me. They were like toys. The people weren't really putting in the technology into them. A lot of times this is like a playground for the intellect of a geeky designer. So you get gear that's impossible for a musician to figure out and doesn't sound good. I went through a lot of that for many years. And then I found this. Well, I mean I didn't find it - it found me! It's a very popular device. Out of any device I've ever used - any effects processor - for my ear this seems to have the most transparency which means its sounds the most like just plugging directly to the front of an amp which is really nice. It's extremely powerful! It's almost like rocket science. I mean, you have to learn how to use it. I mean you can just plug it in and and put up some settings and it's good, but when you start getting into all the parameters of it you can give yourself a hernia with just pushing buttons, haha. That's basically what I use. Now I don't necessarily use it very much on the record because when I record I like to get a very direct signal and then I put various processors from inside, but I did use it on some stuff. This is my rig to use live," says Steve Vai about the Fractal Audio Systems Axe-Fx II Guitar Effects PreAmp Processor.

Since Songs of Innocence, the Edge has been using 4 of these in his rack rig.

Also, in this video by Premier Guitar (https://youtu.be/qDYfXvGuaL4) that can be clearly seen in his effects rack.

"With the amp in the effects loop is actually the Axe-FX II, which we just started using. We were using the Ultras before. The guys from Fractal took all my programs from the Ultra, and [John] only uses one preset, it's all of the effects just kind of like you would have in any other system - delays, choruses, whatever - and we just turn them on and off. They're set, they don't change. So he programmed everything into the Axe-FX II, came out, we put it in the rig and sat there and kind of had to go through stuff and tweak things a little bit. So with the Axe-FX II, the outputs, left and right, come into the effects return. The top amp would be the left side and the bottom amp is the left side, so we get a true stereo thing happening. His effects chain is just very, very simple. Everything is in parallel with the main line of it, so there's nothing too crazy going on," says John Petrucci's guitar tech.

Dave Mustaine has been using the Fractal Axe-Fx II Guitar Effects Processor since 2012, as noted in "Dave Mustaine's Guitars and Gear" on GroundGuitar.

Joe Satriani uses the Fractal Axe-Fx II Guitar Effects Processor as part of his effects setup, as highlighted in the Premier Guitar article "Joe Satriani: Don’t Even Think About It!"

According to Syn's guitar tech, he has two Axe-FX II units in his FX loop (presumably one as a backup). He discussed Syn using them as harmonizers, though no other effects were mentioned.

Tim Henson uses the Fractal Axe-Fx II Guitar Effects Processor, as seen in his Instagram post. Previously, Polyphia relied on POD Farm for their EPs, but this unit is now featured on material from "Muse."

At 4:21, Troy says about the Axe-FX II "Actually, I've gotten quite used to the Fractal. It sounds great, actually. Once you get into all the parameters of all the effects, you can actually make it sound pretty good, pretty much custom." He says later at 5:27, "I'm really using the Axe-FX for reverbs and tap delays. I actually use it also for a sort of like a Uni-Vibe sort of wobbly effect. I also use it for routing stuff to different amps."

Stephan Carpenter shows his Fractal Axe-Fx processors at 3:30 in this rig rundown video.