PRS S2 Custom 22 Semi-Hollow

$1,199.99 Price Tier: Standard

5.0 (4)

1 Review

Find out who is using PRS S2 Custom 22 Semi-Hollow

3 wishlisted

8 saved

Page last updated Jun 24, 2026

Pricing and availability

We compare 600+ stores and found this item at 1 store. Prices updated June 24, 2026.

Store

Reviews

Price

5.0 (13)

$1,199.99 3 available Used

View Deal

Average Price: $1,200

Standard/Professional

$500

$1201+

Price Tier

In the Semi-Hollowbody Electric Guitars category, PRS S2 Custom 22 Semi-Hollow is priced in the upper end of the Standard/Professional range. This is quality gear at a fair price point, suitable for beginners, hobbyists, and pros alike.

Budget

Standard

High-end

^* Product prices and availability are updated by Equipboard every 24hrs and are subject to change. Equipboard may receive compensation for purchases made at participating retailers linked on this site. This compensation does not affect what products or prices are displayed, or the order of prices listed. For more information, please refer to our affiliate disclosure.

Description

Edit description

Discover the harmonious blend of tradition and innovation with the PRS S2 Custom 22 Semi-Hollow, a guitar that redefines versatility and tonal richness. This instrument caters to musicians who seek both the warmth of a semi-hollow body and the precise clarity of an electric guitar. Crafted with a mahogany body and neck, the S2 Custom 22 exudes a resonant and balanced sound, while the elegantly carved flame maple top adds a touch of visual allure.

Equipped with PRS's proprietary 85/15 'S' humbuckers, this guitar delivers a broad tonal palette, offering everything from crisp, clean highs to deep, growling lows. The 25” scale rosewood fretboard ensures smooth playability and comfort, ideal for both intricate solos and powerful chords. A reliable tremolo system adds creative flexibility, allowing you to explore expressive bends and dynamic vibrato with ease.

Whether you're jamming in your garage or performing on stage, the PRS S2 Custom 22 Semi-Hollow promises a playing experience that is both inspiring and dependable, making it a cherished addition to any guitarist's collection.

Key Features:

Mahogany body and neck with beveled flame maple top
Rosewood fretboard with 25” scale
85/15 'S' humbuckers for versatile tonal range
Tremolo system for expressive playing
Semi-hollow body design for enhanced resonance and warmth

Product specs

Brand	PRS
Model	S2 Custom 22 Semi-Hollow
Finish	Amber Smokeburst, Angry Larry Smokeburst, Black Diamond, Burnt Amber Burst, Champagne Gold Metallic, Charcoal Metallic, Dark Cherry Burst, Desert Sand Metallic, Elephant Gray, Faded Blue Smokeburst, Faded Denim Metallic, Faded Whale Blue Smokewrap, Firemist Red Metallic, Golden Blue Burst, Golden Orange Burst, Golden Smokeburst, Jewel Lime Metallic, Lavender Metallic, McCarty Sunburst, Moss Green, Platinum Metallic, Platinum Smokeburst, Purple Firemist, Satin Aqua Metallic, Scarlet Red, Trampas Green Smokeburst, Violin Amber Sunburst, Whale Blue
Year	2016 - 2025
Made In	United States
Categories	Semi-Hollowbody Electric Guitars
Body Material	Mahogany
Body Shape	Double Cutaway
Body Type	Semi-Hollow Body
Bridge/Tailpiece Type	Tremolo Bridge
Color Family	Black, Blue, Brown, Gold, Green, Grey, Orange, Purple, Red, Silver
Finish Features	Matching Headstock
Finish Pattern	Sunburst
Finish Style	Gloss, Metallic
Fretboard Material	Rosewood
Model Family	PRS Custom 22
Model Sub-Family	PRS Custom 22 Semi-Hollow
Neck Construction	Set-Neck
Neck Material	Mahogany
Number of Frets	22
Number of Strings	6-String
Pickup Configuration	HH
Right / Left Handed	Right Handed
Series	PRS S2
Top Material	Maple
Wood Top Style	Flamed

FAQs

What kind of tones can I expect from the PRS S2 Custom 22 Semi-Hollow for rock music?: The PRS S2 Custom 22 Semi-Hollow features 85/15 "S" pickups, offering a versatile tonal range suitable for rock. Expect a balanced sound with clear highs and punchy mids, ideal for both rhythm and lead playing.
How does the semi-hollow design of the PRS S2 Custom 22 affect its sound?: The semi-hollow design provides a warmer, more resonant tone with enhanced sustain compared to solid body guitars. It offers a rich, full sound that's perfect for a variety of genres, including blues and jazz.
Is the PRS S2 Custom 22 Semi-Hollow suitable for live performances?: Yes, the PRS S2 Custom 22 Semi-Hollow is well-suited for live performances, offering reliable tuning stability with its PRS low mass locking tuners and a versatile sound that cuts through the mix.
What is the neck profile like on the PRS S2 Custom 22 Semi-Hollow?: The PRS S2 Custom 22 Semi-Hollow features a "Pattern Regular" neck profile, providing a comfortable grip for most hand sizes, making it suitable for both rhythm and lead playing styles.
Does the PRS S2 Custom 22 Semi-Hollow come with a case?: The PRS S2 Custom 22 Semi-Hollow comes with a gig bag for protection and easy transport, ensuring your guitar is safe whether traveling to gigs or storing at home.
Can the PRS S2 Custom 22 Semi-Hollow handle high-gain settings?: Yes, the PRS S2 Custom 22 Semi-Hollow can handle high-gain settings well, thanks to its 85/15 "S" pickups, which maintain clarity and definition even under heavy distortion.

Videos

Add video

Phillip McKnight

PRS S2 Semi-Hollow Custom 22 comparison to the PRS Hollowbody II and the Custom 22 guitars.

Phillip McKnight

[MusicForce] PRS S2 Custom22 Semi Hollow Demo - ‘Still Feel Like Your Man’ by Guitarist ‘박근’

Music Force Official

PRS S2 Custom 22 Semi Hollow VS CE24 Semi Hollow Review (No Talking)

Music Force Official

[Guitar Review] PRS S2 Custom 22 & Custom 22 Semi-Hollow

Music Force Official

PRS S2 Custom 22 Semi Hollow Tri Color Sunburst - A&C Hamilton Blackpool Road

A&C Hamilton Musical Instruments

First Impressions - Jared Whitman and the S2 Custom 22 Semi-Hollow

PRS Guitars

New Guitar - PRS S2 Custom 22 Semi-Hollow

Mojojojoe

Reviews

Add review

PROS

Exceptional neck and fretboard responsiveness enhances playability
High-quality build with flawless finish and craftsmanship
Lighter and easier to play than many solid-body counterparts
Impressive resonance and sustain, even without an amp
Versatile sound range, from mellow tones to punchy crunch
Semi-hollow design delivers a unique open tone
Reliable tuning stability with effective tremolo system
Eye-catching aesthetic with beautifully crafted woods
Coil tapping feature adds sound versatility
Locking tuners enhance tuning reliability

CONS

Neck might feel too thin for those used to thicker profiles
Inconsistent neck cuts may require in-person purchase to ensure quality

Owner Insights

We analyzed real musician discussions from forums and Reddit to find what players love, question, and tweak about PRS S2 Custom 22 Semi-Hollow.

Features and functionality

0 0

The S2 Custom 22 Semi-Hollow includes PRS 85/15 "S" pickups, known for their versatile and signature PRS tone.
Source
0 0

The trem system is praised for better tuning stability compared to a Strat trem.
Source
0 0

The coil splits are praised for delivering low-noise operation, although they don't perfectly emulate true single coil tones.
Source

User experience

0 0

Owners note that the PRS neck feels wide and effortlessly playable, differing significantly from a typical Strat neck.
Source
0 0

PRS guitars, including the S2 line, are consistently praised for avoiding common issues found in floor models at guitar stores.
Source
0 0

The Custom 22 is frequently chosen over the Custom 24 due to preferred neck feel and pickup position, enhancing its appeal for some players.
Source
0 0

Some players emphasize the need for professional setup to optimize the floating bridge's performance, particularly if unfamiliar with PRS's design compared to Strat bridges.
Source

Comparisons

0 0

The S2 Custom 22 combines attributes of Strat, Tele with humbuckers, and vintage hollow-body guitars in a versatile package.
Source

Build quality

0 0

Owners appreciate the rounded fretboard edges, a feature not commonly highlighted in PRS models, enhancing playability and comfort.
Source

Value and pricing

0 0

Some buyers have acquired satin finish models for under $800, emphasizing their high cost-to-value ratio, especially when discounted.
Source

Setup and maintenance

0 0

Some owners suggest adjusting the trem claw screws in the back to level the bridge, especially after changing to heavier gauge strings.
Source
0 0

It's noted that the PRS bridge is designed to float, allowing pitch bends both up and down, which may require setup adjustments compared to a fixed bridge guitar.
Source
0 0

When adjusting the bridge, detune the strings slightly before tightening the trem claw screws to avoid stressing the wood.
Source

Use cases and applications

0 0

Owners mention that leaving the bridge slightly angled can increase the range for pitch bends, though it may cause the bridge to move more frequently during play.
Source