Pricing and availability

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Sweetwater
3.5 (18)
$299.00
Guitar Center
3.5 (4)
$299.00
Amazon
4.5 (1343)
$299.00 New
$199.55 Used (Very Good)
Reverb
$187.07 New
$140.00 Used
Musician's Friend
4.0 (1)
$299.00
zZounds
5.0 (2)
$249.00
B&H
5.0 (1)
$299.00
Thomann
4.5 (102)
$185.00 $183.00 $2.00 · All time low
Gear4Music
£174.50

Average Price: $250

Standard/Professional

$200

$501+

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Based on price data from 7 merchants for "M-Audio Oxygen Pro 49". Prices shown reflect NEW condition. Tracking began Apr 2, 2026.

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Description

The M-Audio Oxygen Pro 49 is your go-to MIDI controller for both studio and on-the-go music production. This powerful, 49-key USB-powered MIDI controller is packed with features to streamline your creative process and elevate your music-making experience. With its velocity-sensitive, semi-weighted keys with aftertouch, it offers a responsive and expressive playing experience that rivals higher-end models. The easy-to-read OLED screen and intuitive layout ensure that you can focus on your music rather than getting lost in complex settings.

Designed with the modern music creator in mind, the Oxygen Pro 49 includes 16 RGB backlit, velocity-sensitive pads with Note Repeat, perfect for beat production and clip launching. The 8 assignable knobs and 9 faders provide tactile control over your DAWs and virtual instruments, making it easier than ever to bring your ideas to life. The Smart Chord and Smart Scale modes remove technical barriers, letting you focus on creativity by simplifying chord voicings and eliminating wrong notes.

With its Auto-Mapping feature, this controller seamlessly integrates with all major DAWs like Pro Tools, Ableton Live, and Logic, while the included software suite offers a comprehensive set of tools to kickstart your projects. Whether you're an experienced producer or just starting out, the M-Audio Oxygen Pro 49 ensures you have everything you need for a professional workflow.

Key Features:

  • 49 best-in-class, velocity-sensitive, semi-weighted keys with aftertouch and assignable zones
  • 16 RGB, backlit, assignable, velocity-sensitive pads with Note Repeat
  • 8 assignable knobs for controlling virtual instruments, mix plugins, DAW controls, and more
  • 9 assignable faders for controlling levels and perfecting your final mixes
  • Smart Chord mode enables playing of enharmonic or custom chord voicings
  • Smart Scale mode eliminates wrong notes, making it easy to craft a perfect song
  • Arpeggiator with Type, Octave, Gate, and Swing controls
  • Ergonomically designed pitch and modulation wheels & 1/4” sustain pedal input
  • USB-MIDI connection and 5-pin MIDI Output for controlling external MIDI gear
  • Intuitive layout featuring an OLED screen for quick control edits
  • Includes MIDI editor software and a complete software production package: Pro Tools | First M-Audio Edition, MPC Beats, and Ableton Live Lite
  • Virtual instrument collection from AIR Music Tech, including Hybrid 3, Velvet, Mini Grand, Vacuum, Boom, and DB-33
  • A collection of Expansion Packs from Akai Professional's legendary MPC Series

Owner's manual

M-Audio Oxygen Pro 49 User Manual

Product specs

Available since November 2020
Aftertouch Yes
Split Zones 1
Layer function No
Pitch Bend / Modulation Yes
Rotary Encoder 8
Fader 9
Pads 16
Display Yes
Sustain Pedal Connection Yes
USB-port Yes
Mains Operation No
Battery Operation No
Bus-Powered Yes
Dimensions 800 x 264 x 84
Weight in kg 4,2 kg
Special Features N/A

FAQs

Does the M-Audio Oxygen Pro 49 work with Ableton Live?

Yes, the M-Audio Oxygen Pro 49 is compatible with Ableton Live and comes with Ableton Live Lite software, making it easy to integrate into your DAW setup.

What are the key features of the M-Audio Oxygen Pro 49?

The M-Audio Oxygen Pro 49 features 49 velocity-sensitive, semi-weighted keys with aftertouch, 16 pads, 8 rotary encoders, and 9 faders, offering extensive control for music production.

Is the M-Audio Oxygen Pro 49 suitable for live performances?

Yes, the M-Audio Oxygen Pro 49 is well-suited for live performances with its semi-weighted keys, aftertouch, and comprehensive control options, allowing for expressive and dynamic play.

Can the M-Audio Oxygen Pro 49 be powered without a computer?

The M-Audio Oxygen Pro 49 is bus-powered via USB and cannot be powered independently without a computer or USB power source.

Does the M-Audio Oxygen Pro 49 have aftertouch?

Yes, the M-Audio Oxygen Pro 49 features aftertouch, allowing for expressive control over your sound by responding to the pressure applied to the keys after they are pressed.

Eric C. Powell Music

Eric C. Powell Music

M-Audio Oxygen Pro 49 MIDI Controller - Setup and Demo

Video thumbnail for M-Audio Oxygen Pro 49 MIDI Controller - Setup and Demo by Eric C. Powell Music

M-Audio Oxygen Pro 49 MIDI Controller - Setup and Demo

Eric C. Powell Music

Eric C. Powell Music

Video thumbnail for M-Audio Oxygen Pro 49 Unboxing and iOS Demo by Fretless33 Bass (Fretless33)

M-Audio Oxygen Pro 49 Unboxing and iOS Demo

Fretless33 Bass (Fretless33)

Fretless33 Bass (Fretless33)

Video thumbnail for Watch This Before You Buy!!!| M-Audio Oxygen Pro 49 Midi Keyboard Controller Review by Black Universe

Watch This Before You Buy!!!| M-Audio Oxygen Pro 49 Midi Keyboard Controller Review

Black Universe

Black Universe

Video thumbnail for M Audio Oxygen Pro 49 Loop Performance by Golden Productions

M Audio Oxygen Pro 49 Loop Performance

Golden Productions

Golden Productions

Reviews

PROS

  • High-quality build and durable

  • Versatile with many DAW presets included

  • Semi-weighted keys feel realistic and responsive

  • Standalone functionality without a computer

  • Zone aftertouch with 4 MIDI zones and presets

  • Extensive DAW control features, especially with Reaper

  • Adjustable sensitivity on pads

  • Built-in arpeggiator and extensive control options

  • Good value for the price

CONS

  • Software issues with Mac OS Sonoma

  • Complicated setup process for firmware and software

  • Drum pad programming in Logic is cumbersome

  • Tempo synchronization issues with Logic

  • Small screen with limited functions

  • Pitch drift problem over time

  • Aftertouch requires significant pressure to activate

Owner Insights

We analyzed real musician discussions from forums and Reddit to find what players love, question, and tweak about M-Audio Oxygen Pro 49.

Setup and maintenance

  • Keys may feel sticky after periods of inactivity, but it doesn't affect playability after initial presses.

    Source
  • Some owners recommend using Bome's MIDI Translator to convert MIDI signals into keyboard shortcuts for better FL Studio integration.

    Source

User experience

  • Owners appreciate the improved feel of the encoders and sliders compared to previous M-Audio models.

    Source
  • Users report initial difficulty with programming presets, despite years of MIDI controller use.

    Source
  • Support response from M-Audio can be slow, with some users waiting extended periods for assistance.

    Source
  • It's noted that the Oxygen Pro 49 has not been reported to suffer from the encoder problems that plagued the M-Audio Code series.

    Source

Software and compatibility

  • ItsGratuiTous offers a free MIDI Script specifically for the Oxygen Pro to enhance FL Studio integration.

    Source
  • Reaper users achieved success by setting the DAW to "Mackie Universal" control mode, avoiding MIDI3 output to prevent unusual behaviors.

    Source
  • Automapping issues are reported in FL Studio, requiring users to create custom scripts for functionality.

    Source

Features and functionality

  • Preset Mode, not DAW Mode, is recommended for smoother operations in FL Studio.

    Source
  • The Preset Editor requires enabling advanced options for full functionality, allowing custom preset creation.

    Source
  • The M-Audio Oxygen Pro 49 features semi-weighted keys and channel aftertouch which are highlighted as improvements over the original Oxygen series.

    Source
  • The pitch wheel is noted for lagging and not tracking accurately, affecting quick pitch changes.

    Source

Build quality

  • Some users experience screen burn-in within three months, making text difficult to read.

    Source
  • The M-Audio Oxygen Pro 49 is noted for its plastic construction, while alternatives like the Akai MPK249 offer more robust metal builds.

    Source

Use cases and applications

  • It's mentioned that the Oxygen Pro 49 provides a good beatmaking experience when used with Virtual Instruments in DAWs like FL Studio.

    Source

Comparisons

  • Some owners suggest the Novation Impulse for better keyboard quality and Automap functionality compared to the Oxygen Pro 49.

    Source

Critic Reviews

M-Audio Oxygen Pro 49

soundonsound.com

The M-Audio Oxygen Pro 49 is a solid MIDI controller that balances performance features with user programmability. Its lightweight design, full-size keys, and responsive pads make it versatile for various setups. However, its DAW integration feels underdeveloped, lacking essential features like parameter labeling and aftertouch on pads, which may frustrate some users. While the build quality is commendable, the key action is described as more budget-oriented. Despite these drawbacks, the Oxygen Pro 49 offers a generous software bundle and sufficient functionality for beginners and seasoned musicians alike. Ultimately, it’s a capable choice, but with noticeable room for improvement.

M-Audio Oxygen Pro 49 review | MusicRadar

musicradar.com

M-Audio's Oxygen Pro 49 revitalizes the keyboard controller scene with its sleek design and impressive feature set, including Chord and Scale Modes for enhanced creativity. The responsive pads and deep DAW integration are standout aspects that elevate performance. However, the keyboard's lightweight feel and a learning curve for some features may deter certain users. Overall, it’s a solid choice for musicians seeking affordability without sacrificing functionality.

positive

M-Audio Oxygen Pro 49 Review - AudioNewsRoom (ANR)

audionewsroom.net

The M-Audio Oxygen Pro 49 delivers solid performance with its semi-weighted keys and useful features like Smart Chord and Smart Scale, making it a commendable choice for budget-conscious musicians. While the build quality is robust and the OLED screen impressively clear, the aftertouch feature proves tricky, requiring more force than some might expect. The controller shines with its drum pads and decent software bundle, but those seeking high-end functionality may want to look elsewhere. Ultimately, the Oxygen Pro 49 is a reliable option, although it doesn't quite reach the heights of pricier competitors.

5.0 out of 5

Based on 0 Reviews and 4 Ratings

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Artist usage

Add artist
See how Cameron Winter uses M-Audio Oxygen Pro 49

Cameron Winter

Singer, Guitarist

Geese

...
Verified via Photo

At the 2:00 mark of the video, Cameron Winter is seen using the M-Audio Oxygen Pro 49, identifiable by the distinct arrangement of knobs and sample pads on the left side.

See how Lorenzo Scarponi uses M-Audio Oxygen Pro 49

Lorenzo Scarponi

Keyboardist, Composer

dogflesh

...
Verified via YouTube

Lorenzo Scarponi confirmed his use of the M-Audio Oxygen Pro 49 during a conversation after his live show. This is further supported by the video "dogflesh - Live at Substrato, PZ [Black Spell, 15/05/26]" on YouTube by user dogflesh.

Genre Usage

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Used With

Based on how musicians on Equipboard use M-Audio Oxygen Pro 49, it is most commonly used with the following gear.

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