Kurt used the Sansamp as his primary distortion on the In Utero album and tour. His settings were '3 up, 3 down, 2 up' on the switches, both drive knobs were full, high from 11-2 o clock, in normal mode.

Thom Yorke used the Tech 21 SansAmp Classic for his guitar during the Atoms for Peace DJ shows in 2013, which allowed his signal to run directly into his mixer. This is supported by an image available on Equipboard.

Calvin answered a tweed by DJ White Pepper regarding what he used to record the guitar for 'Outside'. He tweeted back with This Photo of his sansamp classic. He also used a Gibson SG Custom.

In this archived article from Guitar World magazine's April 2000 issue, the SansAmp Classic is listed in the sidebar as being one of Robert's effects.

"Well, when I'm at home, there are two ways I do it. I've got my Marshall heads that have recording outputs, which are really amazing sounding. The recording out feature on the new Marshall heads is so reliable and it sounds organic. So if I really want the amp head sounds, I'll do that.

But I'll tell you what I started doing about two years ago, is recording DI and using software guitar amplification, primarily because I thought if I put in a performance that's a once-in-a-lifetime performance on this particular song, I'm going to want to keep it. And I don't trust doing it here at home. But if I record it direct, it'll sit there in the session and then when we get to a real studio and we've got the real band recorded with microphones and a big room, we can re-amp that performance, and re-record it. And that's what we did quite a bit for the Black Swans and Wormhole Wizards record. There are quite a few songs that I had recorded using SansAmp or Guitar Rig, but they were all recorded DI. I would monitor those software patches at home, and then when we got to Skywalker, we either used a combination of those software guitar patches, or we would send the DI out into Marshall amps and different speakers and mic them anyway we want based on what we had captured from the band.

(...)

I remember the first time we used a SansAmp, John and I were recording Flying in a Blue Dream, and they had just created one and he was hip to the idea of 'hey let's use SansAmp so we get out of the hassle of trying match guitar parts in different studios,' because we were kind of moving around a lot at the time. One song might get recorded in three places and he was thinking this was going to be insane for Joe's guitar sound unless we can take it with us. And we had done that before, going directly into mic pres or using the Tom Scholz Rockman and we tried every little funny piece of gear, because we were trying to do anything that was the antithesis of mic'ing up a Marshall stack."

During Metallica's 1989 Seattle concert, featured in the video "Metallica - Live Shit Binge & Purge," Jason Newsted's Tech 21 SansAmp Classic is visible next to his wah pedal during the performance of "Blackened." The word "Classic" can be clearly seen on the pedal.

Kurt Cobain gifted a Tech 21 SansAmp Classic to Pat Smear for his pedalboard. While Pat owns the SansAmp, he opted to use a ProCo Rat during live performances due to personal preference. This is supported by a user-uploaded photo.

Part of the Lunar Module Soundscapes System used on all work between 1994 to 2005 (RF Soundscapes, RFSQ, KC, Sylvian & Fripp, Eno's Nerve Net, etc)

pedal used in the Last Concert Tour with Soda Stereo in the year 1997.

Used during King Krule's NPR Tiny Desk performance.

In a photo from a SubPop record gallery, Nate Mendel (crouching, bottom left) is clearly seen setting up a Tech 21 SansAmp Classic with his right hand , holding a power supply unit in his left hand.

In the user-uploaded photo, Jeff Ament is shown using the Tech 21 SansAmp Classic distortion effects pedal.