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M-Audio Oxygen 49 MKII 49-Key USB MIDI Keyboard Controller

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M-Audio Oxygen 49 MKII 49-Key USB MIDI Keyboard Controller

$104.57 Price Tier: Budget

4.5 (108)

29 Reviews

Newer option

M-Audio Oxygen 49 MK4

$168.50 - $299.00

4.0 (58)

Find out who is using M-Audio Oxygen 49

2 community setups

15 wishlisted

215 saved

Page last updated Jul 04, 2026

Pricing and availability

We compare 600+ stores and found this item at 1 store. Prices updated July 4, 2026.

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Price

$104.57 1 available Used

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Average Price: $105

Budget/Beginner

$200

$501+

Price Tier

In the MIDI Keyboard Controllers category, M-Audio Oxygen 49 MKII 49-Key USB MIDI Keyboard Controller is priced in the Budget/Beginner range. This is great gear to get started with or for creators on a budget.

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Description

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Unleash your creative potential with the M-Audio Oxygen 49 MKII 49-Key USB MIDI Keyboard Controller, a versatile and intuitive tool designed for modern musicians and producers. This 49-key controller combines a user-friendly interface with robust functionality, making it an ideal companion for both studio sessions and live performances. Equipped with velocity-sensitive keys, it offers expressive performance capabilities, while the wide array of control options provides seamless integration with your favorite DAWs and virtual instruments.

Featuring eight assignable knobs, nine faders, and dedicated transport controls, the Oxygen 49 MKII allows for hands-on control of your music production software, offering an immersive, tactile experience. The DirectLink mode automatically maps these controls to the most important functions of popular DAWs such as Ableton Live, Pro Tools, Logic, and more, saving you time and enhancing your workflow. Additionally, its plug-and-play USB connectivity ensures straightforward setup, while MIDI output expands its compatibility with external hardware.

The Oxygen 49 MKII also includes a suite of premium software instruments and effects to inspire your creativity right out of the box. Whether you're a seasoned producer or just starting out, this MIDI keyboard controller provides the tools you need to transform your musical ideas into reality.

Key Features:

49 full-size, velocity-sensitive keys for expressive performance
Eight assignable knobs, nine assignable faders, and transport controls for comprehensive DAW integration
DirectLink mode for automatic mapping with popular DAWs
Plug-and-play USB connectivity for easy setup
MIDI output for connecting to external hardware
Includes a suite of premium software instruments and effects

Product specs

Brand	M-Audio
Model	Oxygen 49 MKII MIDI Keyboard Controller
Finish	Blue
Year	2010 - 2014
Categories	Keyboard MIDI Controllers, Pad MIDI Controllers
Analog / Digital	Digital
Key Size	Full Size
Keyboard Action	Synth Action
MIDI I/O	USB MIDI
Number of Keys	49 Keys

FAQs

Is the M-Audio Oxygen 49 MKII compatible with popular DAWs like Ableton Live and Pro Tools?: Yes, the M-Audio Oxygen 49 MKII is compatible with most major DAWs, including Ableton Live and Pro Tools. It features assignable controls and integration for seamless workflow.
Does the M-Audio Oxygen 49 MKII require external power or is it bus-powered?: The M-Audio Oxygen 49 MKII is USB bus-powered, meaning it draws power directly from your computer via the USB connection, eliminating the need for an external power supply.
What type of keys does the M-Audio Oxygen 49 MKII have?: The M-Audio Oxygen 49 MKII features synth-action keys, which are lightweight and responsive, suitable for playing a wide range of musical styles.
Can I use the M-Audio Oxygen 49 MKII to control virtual instruments?: Yes, the M-Audio Oxygen 49 MKII is designed to control virtual instruments and plugins, offering assignable knobs, sliders, and transport controls for enhanced music production.
How many assignable controls are available on the M-Audio Oxygen 49 MKII?: The M-Audio Oxygen 49 MKII provides eight assignable knobs and nine assignable sliders, allowing for extensive customization and control over your music software.

Videos

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Willy Eklof

M Audio Oxygen 49 & Ableton Live Demo

Willy Eklof

M-Audio Oxygen 49 Usb Midi Controller Review

MW Technology

M-Audio Oxygen 49 3rd Gen Review & Unboxing. test with Garageband.

MusicReview

M-Audio Oxygen 49 Midi Keyboard Unboxing! (Setup for Fl Studio 11)

Rain Man

M-Audio Oxygen 49

M-Audio

Reviews

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PROS

Eight assignable knobs and nine sliders enhance DAW control
DirectLink mode automatically maps controls to common DAW functions
Built-in factory presets support popular virtual instruments
Velocity-sensitive keys for expressive playing
Lightweight and portable, ideal for production and performance
Transport controls and "synth action" keys for tactile feedback
Compatible with various DAW plugins and virtual instruments
Customizable controls for personalized setup
Attractive for beginners with its easy-to-use interface
Good value for its price, offering many controls

CONS

Dynamic response not very sensitive
User interface and LED display can be confusing
Some users report issues with faders popping off
Modulation value may jump unexpectedly
Drum pads may not map well with certain DAWs
Some users find the key action quality poor
Random CC values issue reported by a user

Owner Insights

We analyzed real musician discussions from forums and Reddit to find what players love, question, and tweak about M-Audio Oxygen 49 MKII 49-Key USB MIDI Keyboard Controller.

Build quality

0 0

Some users report that key contacts can stop working, potentially turning the keyboard into a non-functional unit without repair options.
Source

Software and compatibility

0 0

Older models may experience USB driver issues; however, using the DIN output can circumvent this problem.
Source

Value and pricing

0 0

The bundled software that comes with new units significantly contributes to their retail price, which is not included in second-hand purchases.
Source

Comparisons

0 0

Older revisions of the M-Audio Oxygen 49 have less desirable key feel compared to newer models like the Launchkey Mini or Akai MPK Mini.
Source
0 0

The Arturia Keystep 37 is noted for having an arpeggiator, a feature lacking in many 49-key models, highlighting a unique offering for users needing this function.
Source

Features and functionality

0 0

The mk3 model is noted for its synth-action keys, which can feel stiff initially but become comfortable over time with use.
Source
0 0

The M-Audio Oxygen 49's knobs and buttons can be mapped to various DAW controls, providing hands-on tweaking without needing to use a mouse.
Source

User experience

0 0

Owners of the Keystation 61 mk3 appreciate its compactness and essential features, like transposition and modulation wheels, despite lacking advanced functions like an arpeggiator.
Source

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4.5 out of 5

Based on 29 Reviews and 108 Ratings

5 star

4 star

3 star

2 star

1 star

krzakson8

121

over 6 years ago

Pretty good

M-Audio Oxygen 49 is overall not bad midi keyboard. It has some dynamic response but its not very sensitive. The sliders and knobs are still working on my product. The thing is that user interface in combination with LED display can be confusing at times in my opinion but the price of this product makes me not taking out 2nd star for that one. Overall its good product for the price.

szczepaxn

207

over 8 years ago

Powerful MIDI control device

Oxygen 49 features eight assignable knobs and nine assignable sliders, plus dedicated transport and track select buttons. DirectLink mode automatically maps these controls to common DAW functions including transport, mixer, track pan and plug-in parameters. Built-in factory presets offer support for popular virtual instruments right out of the box—no complicated setup required. Velocity-sensitive keys and a sleek, compact design round out a portable keyboard that’s perfect for both production and performance. No other MIDI controller in this price range has so much functionality while remaining easy to use.

Roles:

Keyboardist Rapper Composer

Genres:

Electronic Hip Hop Funk / Soul

soundsbyangel

128

over 9 years ago

M-Audio Midi Keyboard

The M-Audio Oxygen is what I use to play all the VTS inside MainStage. It is also fully custom midi-mapped to control my live loopers, select pre-sets, and toggle between different live inputs and mute them as needed.

jhon_shepherd

407

about 7 years ago

First Full Key Controller

This was my first 49 key MIDI controller and its not a bad controller at all from what I remember. Though I wish I had not rid of it so quickly, Things worked themselves out and she is indeed in a good home.

polarity

114

almost 7 years ago

Its an okay keyboard.

I have two of them. On one keyboard the key broke after a year and the other one is sending out random cc informations (sometimes).

warrickluther

over 9 years ago

Simple, Satisfactory

Simple Midi Keyboard. Nothing fancy, but it does the job just fine. Would recommend some sort of case for it as the faders have the tendency to pop off from time to time. They are easily re-attachable however.

zylark

151

over 10 years ago

Love It!

Works will all DAW plugins ive tried it on, velocity-sensitive keys and drumpad work great! The only problem ive ever had with this was the modulation value jumping from 0 to 1, but it does not affect the sound of anything really.

djfriendzone

303

over 12 years ago

Fantastic key action

Its a great piece of gear and it has transport controls which is a nice touch. The keys have a very nice springy "synth action" (like the Virus keys), and the whole thing is very lightweight and reliable.

backslash

244

almost 13 years ago

Compact and convenient MIDI controller for your workspace

Great MIDI controller just for my needs. And it fits directly on my table!

From Gear Setup

windowlicker9

589

over 10 years ago

Good MIDI kepboard for the price

Even though the build feels a bit cheap, the controls offered by this thing are good for the price. It has velocity, 8 drum pads, 8 contol knobs, and 9 fader knobs