Using this beautiful card over ADAT lightpipes to bring 52 duplex channels in and out of my Mackie D8B running at 48kHz may be very much yesterday's tech, but it works for me. The sound of the converters gets me the results I and my clients are after, so I can't fault this card/console combination. As for support, RME keep the drivers and console software bang up to date, so as long as your motherboard offers legacy PCI slots and you use ADAT interfacing and want MIDI into the bargain, you're in luck because second-hand, they are dirt cheap given their lovely quality.
Only use these I/O's for putting in and out signals (through A/D D/A's for front ends) so, I only consider about how solid the driver is, and the cost performance. Super good driver and Utilities are bundled with this, they are great. Only thing is, using the exclusive driver on Win isn't good, so u'll might need another one to use in common. Again, super stable in DAW's, and there's no replacements for the utilities!